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Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats
Ulusu, Nuray Nuriye; Gök, Müslüm; Sayın Şakul, Arzu Ayşe; Arı, Nuray; Stefek, Milan; Karasu, Çimen (Slovak Toxicology Society, 2017)The pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems. This study investigated the effects of the powerful antioxidant SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2 ... -
A pyridoindole antioxidant SMe1EC2 regulates contractility, relaxation ability, cation channel activity, and protein-carbonyl modifications in the aorta of young and old rats with or without diabetes mellitus
Sayın Şakul, Arzu; Arı, Nuray; Sotnikova, Ruzenna; Ozansoy, Gülgün; Karasu, Çimen (Springer, 2018)We studied the effects of treatment with SMe1EC, a hexahydropyridoindole antioxidant, on vascular reactivity, endothelial function, and oxidonitrosative stress level of thoracic aorta in young and old rats with or without ...